A missense mutation in Grm6 reduces but does not eliminate mGluR6 expression or rod depolarizing bipolar cell function

GRM6 encodes the metabotropic glutamate receptor 6 (mGluR6) used by retinal depolarizing bipolar cells (DBCs). Mutations in GRM6 lead to DBC dysfunction and underlie the human condition autosomal recessive complete congenital stationary night blindness. Mouse mutants for Grm6 are important models fo...

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Vydáno v:J Neurophysiol
Hlavní autoři: Peachey, Neal S., Hasan, Nazarul, FitzMaurice, Bernard, Burrill, Samantha, Pangeni, Gobinda, Karst, Son Yong, Reinholdt, Laura, Berry, Melissa L., Strobel, Marge, Gregg, Ronald G., McCall, Maureen A., Chang, Bo
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5539458/
https://ncbi.nlm.nih.gov/pubmed/28490646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00888.2016
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