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Drosophila Cancer Models Identify Functional Differences Between Ret Fusions
We generated and compared Drosophila models of RET fusions CCDC6-RET and NCOA4-RET. Both RET fusions directed cells to migrate, delaminate, and undergo EMT, and both resulted in lethality when broadly expressed. In all phenotypes examined NCOA4-RET was more severe than CCDC6-RET, mirroring their eff...
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| Publicado no: | Cell Rep |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5858711/ https://ncbi.nlm.nih.gov/pubmed/27626672 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.08.019 |
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