Combination of the low anticoagulant heparin CX-01 with chemotherapy for the treatment of acute myeloid leukemia

Relapses in acute myelogenous leukemia (AML) are a result of quiescent leukemic stem cells (LSCs) in marrow stromal niches, where they resist chemotherapy. LSCs employ CXCL12/CXCR4 to home toward protective marrow niches. Heparin disrupts CXCL12-mediated sequestration of cells in the marrow. CX-01 i...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Blood Adv
मुख्य लेखकों: Kovacsovics, Tibor J., Mims, Alice, Salama, Mohamed E., Pantin, Jeremy, Rao, Narayanam, Kosak, Ken M., Ahorukomeye, Peter, Glenn, Martha J., Deininger, Michael W. N., Boucher, Kenneth M., Bavisotto, Linda M., Gutierrez-Sanchez, Gerardo, Kennedy, Thomas P., Marcus, Stephen G., Shami, Paul J.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society of Hematology 2018
विषय:
Clinical Trials and Observations
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5858478/
https://ncbi.nlm.nih.gov/pubmed/29467192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017013391
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