Osteogenic protein-1 attenuates apoptosis and enhances matrix synthesis of nucleus pulposus cells under high magnitude compression though inhibiting the p38 MAPK pathway

Disc degeneration is correlated with mechanical load. Osteogenic protein-1 (OP-1) is potential to regenerate degenerative disc. To investigate whether OP-1 can protect against high magitude compression-induced nucleus pulposus (NP) cell apoptosis and NP matrix catabolism, and its potential mechanism...

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Detalhes bibliográficos
Publicado no:Biosci Rep
Main Authors: Fang, Haolin, Li, Xianzhou, Shen, Haiming, Sun, Buwei, Teng, Haijun, Li, Pei
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5857901/
https://ncbi.nlm.nih.gov/pubmed/29440560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20180018
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