Experimental Demyelination and Axonal Loss Are Reduced in MicroRNA-146a Deficient Mice

BACKGROUND: The cuprizone (CPZ) model of multiple sclerosis (MS) was used to identify microRNAs (miRNAs) related to in vivo de- and remyelination. We further investigated the role of miR-146a in miR-146a-deficient (KO) mice: this miRNA is differentially expressed in MS lesions and promotes different...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Martin, Nellie A., Molnar, Viktor, Szilagyi, Gabor T., Elkjaer, Maria L., Nawrocki, Arkadiusz, Okarmus, Justyna, Wlodarczyk, Agnieszka, Thygesen, Eva K., Palkovits, Miklos, Gallyas, Ferenc, Larsen, Martin R., Lassmann, Hans, Benedikz, Eirikur, Owens, Trevor, Svenningsen, Asa F., Illes, Zsolt
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5857529/
https://ncbi.nlm.nih.gov/pubmed/29593734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00490
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