Experimental Demyelination and Axonal Loss Are Reduced in MicroRNA-146a Deficient Mice

BACKGROUND: The cuprizone (CPZ) model of multiple sclerosis (MS) was used to identify microRNAs (miRNAs) related to in vivo de- and remyelination. We further investigated the role of miR-146a in miR-146a-deficient (KO) mice: this miRNA is differentially expressed in MS lesions and promotes different...

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Bibliografski detalji
Izdano u:Front Immunol
Glavni autori: Martin, Nellie A., Molnar, Viktor, Szilagyi, Gabor T., Elkjaer, Maria L., Nawrocki, Arkadiusz, Okarmus, Justyna, Wlodarczyk, Agnieszka, Thygesen, Eva K., Palkovits, Miklos, Gallyas, Ferenc, Larsen, Martin R., Lassmann, Hans, Benedikz, Eirikur, Owens, Trevor, Svenningsen, Asa F., Illes, Zsolt
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2018
Teme:
Immunology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5857529/
https://ncbi.nlm.nih.gov/pubmed/29593734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00490
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