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Effects of spinal non-viral interleukin-10 gene therapy formulated with D-mannose in neuropathic interleukin-10 deficient mice: behavioral characterization, mRNA and protein analysis in pain relevant tissues
Studies show that spinal (intrathecal; i.t.) interleukin-10 (IL-10) gene therapy reverses neuropathic pain in animal models, and co-administration with the mannose receptor (MR; CD206) ligand D-mannose (DM) greatly improves therapeutic efficacy. However, the actions of endogenous IL-10 may be requir...
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| Udgivet i: | Brain Behav Immun |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5857419/ https://ncbi.nlm.nih.gov/pubmed/29113923 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2017.11.004 |
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