An AAV-derived Apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinson's disease

Adeno-associated virus (AAV) vector delivery of an Apaf-1-dominant negative inhibitor was tested for its antiapoptotic effect on degenerating nigrostriatal neurons in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of Parkinson's disease. The wild-type caspase recruitment domain of...

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Detalhes bibliográficos
Main Authors: Mochizuki, Hideki, Hayakawa, Hideki, Migita, Makoto, Shibata, Mamoru, Tanaka, Ryota, Suzuki, Asuka, Shimo-Nakanishi, Yumi, Urabe, Takao, Yamada, Masanori, Tamayose, Kenji, Shimada, Takashi, Miura, Masayuki, Mizuno, Yoshikuni
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC58574/
https://ncbi.nlm.nih.gov/pubmed/11535810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.191107398
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