An AAV-derived Apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinson's disease

Adeno-associated virus (AAV) vector delivery of an Apaf-1-dominant negative inhibitor was tested for its antiapoptotic effect on degenerating nigrostriatal neurons in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of Parkinson's disease. The wild-type caspase recruitment domain of...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Mochizuki, Hideki, Hayakawa, Hideki, Migita, Makoto, Shibata, Mamoru, Tanaka, Ryota, Suzuki, Asuka, Shimo-Nakanishi, Yumi, Urabe, Takao, Yamada, Masanori, Tamayose, Kenji, Shimada, Takashi, Miura, Masayuki, Mizuno, Yoshikuni
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2001
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC58574/
https://ncbi.nlm.nih.gov/pubmed/11535810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.191107398
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge