Caspase-11 Mediates Inflammatory Dopaminergic Cell Death in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson's Disease

The present study was designed to elucidate the inflammatory and apoptotic mechanisms of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in a model of Parkinson's disease. Our results showed that mutant mice lacking the caspase-11 gene were significantly more resistant...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Furuya, Tsuyoshi, Hayakawa, Hideki, Yamada, Masanori, Yoshimi, Kenji, Hisahara, Shin, Miura, Masayuki, Mizuno, Yoshikuni, Mochizuki, Hideki
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2004
Assuntos:
Neurobiology of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6730410/
https://ncbi.nlm.nih.gov/pubmed/14985426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3309-03.2004
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