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Pharmacodynamics, Safety, and Tolerability of the NHE3 Inhibitor Tenapanor: Two Trials in Healthy Volunteers

BACKGROUND: Tenapanor, a small molecule with minimal systemic availability, is a first-in-class sodium/hydrogen exchanger 3 (NHE3) inhibitor that acts in the gut. Here, we evaluate the pharmacodynamics and safety of tenapanor in healthy adults. METHODS: Two phase I, single-center, randomized, double...

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書誌詳細
出版年:Clin Drug Investig
主要な著者: Rosenbaum, David P., Yan, Andrew, Jacobs, Jeffrey W.
フォーマット: Artigo
言語:Inglês
出版事項: Springer International Publishing 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856883/
https://ncbi.nlm.nih.gov/pubmed/29363027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40261-017-0614-0
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