Calcineurin-mediated IL-2 production by CD11c(high)MHCII(+) myeloid cells is crucial for intestinal immune homeostasis

The intestinal immune system can respond to invading pathogens yet maintain immune tolerance to self-antigens and microbiota. Myeloid cells are central to these processes, but the signaling pathways that underlie tolerance versus inflammation are unclear. Here we show that mice lacking Calcineurin B...

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Pubblicato in:Nat Commun
Autori principali: Mencarelli, Andrea, Khameneh, Hanif Javanmard, Fric, Jan, Vacca, Maurizio, El Daker, Sary, Janela, Baptiste, Tang, Jing Ping, Nabti, Sabrina, Balachander, Akhila, Lim, Tong Seng, Ginhoux, Florent, Ricciardi-Castagnoli, Paola, Mortellaro, Alessandra
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856784/
https://ncbi.nlm.nih.gov/pubmed/29549257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03495-3
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