Phosphodiesterase type 4 inhibition enhances nitric oxide- and hydrogen sulfide-mediated bladder neck inhibitory neurotransmission

Nitric oxide (NO) and hydrogen sulfide (H(2)S) play a pivotal role in nerve-mediated relaxation of the bladder outflow region. In the bladder neck, a marked phosphodiesterase type 4 (PDE4) expression has also been described and PDE4 inhibitors, as rolipram, produce smooth muscle relaxation. This stu...

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Udgivet i:Sci Rep
Main Authors: Agis-Torres, Ángel, Recio, Paz, López-Oliva, María Elvira, Martínez, María Pilar, Barahona, María Victoria, Benedito, Sara, Bustamante, Salvador, Jiménez-Cidre, Miguel Ángel, García-Sacristán, Albino, Prieto, Dolores, Fernandes, Vítor S., Hernández, Medardo
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856743/
https://ncbi.nlm.nih.gov/pubmed/29549279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22934-1
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