Phosphodiesterase type 4 inhibition enhances nitric oxide- and hydrogen sulfide-mediated bladder neck inhibitory neurotransmission

Nitric oxide (NO) and hydrogen sulfide (H(2)S) play a pivotal role in nerve-mediated relaxation of the bladder outflow region. In the bladder neck, a marked phosphodiesterase type 4 (PDE4) expression has also been described and PDE4 inhibitors, as rolipram, produce smooth muscle relaxation. This stu...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Agis-Torres, Ángel, Recio, Paz, López-Oliva, María Elvira, Martínez, María Pilar, Barahona, María Victoria, Benedito, Sara, Bustamante, Salvador, Jiménez-Cidre, Miguel Ángel, García-Sacristán, Albino, Prieto, Dolores, Fernandes, Vítor S., Hernández, Medardo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856743/
https://ncbi.nlm.nih.gov/pubmed/29549279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22934-1
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge