Evaluating Mismatch Repair Deficiency in Pancreatic Adenocarcinoma: Challenges and Recommendations

PURPOSE: Immune checkpoint inhibition has been shown to generate profound and durable responses in MMR-D solid tumors and has elicited interest in detection tools and strategies to guide therapeutic decision-making. Herein we address questions on the appropriate screening, detection methods, patient...

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Bibliografski detalji
Izdano u:Clin Cancer Res
Glavni autori: Hu, Zishuo I., Shia, Jinru, Stadler, Zsofia K., Varghese, Anna M., Capanu, Marinela, Salo-Mullen, Erin, Lowery, Maeve A., Diaz, Luis A., Mandelker, Diana, Yu, Kenneth H., Zervoudakis, Alice, Kelsen, David P., Iacobuzio-Donahue, Christine A., Klimstra, David S., Saltz, Leonard B., Sahin, Ibrahim H., O’Reilly, Eileen M.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856632/
https://ncbi.nlm.nih.gov/pubmed/29367431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-3099
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