Host biotin is required for liver stage development in malaria parasites

Acetyl-CoA carboxylase (ACC) is a biotin-dependent enzyme that is the target of several classes of herbicides. Malaria parasites contain a plant-like ACC, and this is the only protein predicted to be biotinylated in the parasite. We found that ACC is expressed in the apicoplast organelle in liver- a...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Dellibovi-Ragheb, Teegan A., Jhun, Hugo, Goodman, Christopher D., Walters, Maroya S., Ragheb, Daniel R. T., Matthews, Krista A., Rajaram, Krithika, Mishra, Satish, McFadden, Geoffrey I., Sinnis, Photini, Prigge, Sean T.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2018
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PNAS Plus
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856565/
https://ncbi.nlm.nih.gov/pubmed/29483266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1800717115
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