Expanded cellular clones carrying replication-competent HIV-1 persist, wax, and wane

The latent reservoir for HIV-1 in resting CD4(+) T cells is a major barrier to cure. Several lines of evidence suggest that the latent reservoir is maintained through cellular proliferation. Analysis of this proliferative process is complicated by the fact that most infected cells carry defective pr...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Wang, Zheng, Gurule, Evelyn E., Brennan, Timothy P., Gerold, Jeffrey M., Kwon, Kyungyoon J., Hosmane, Nina N., Kumar, Mithra R., Beg, Subul A., Capoferri, Adam A., Ray, Stuart C., Ho, Ya-Chi, Hill, Alison L., Siliciano, Janet D., Siliciano, Robert F.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2018
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856552/
https://ncbi.nlm.nih.gov/pubmed/29483265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1720665115
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