Bone degradation machinery of osteoclasts: An HIV-1 target that contributes to bone loss

Bone deficits are frequent in HIV-1–infected patients. We report here that osteoclasts, the cells specialized in bone resorption, are infected by HIV-1 in vivo in humanized mice and ex vivo in human joint biopsies. In vitro, infection of human osteoclasts occurs at different stages of osteoclastogen...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Raynaud-Messina, Brigitte, Bracq, Lucie, Dupont, Maeva, Souriant, Shanti, Usmani, Shariq M., Proag, Amsha, Pingris, Karine, Soldan, Vanessa, Thibault, Christophe, Capilla, Florence, Al Saati, Talal, Gennero, Isabelle, Jurdic, Pierre, Jolicoeur, Paul, Davignon, Jean-Luc, Mempel, Thorsten R., Benichou, Serge, Maridonneau-Parini, Isabelle, Vérollet, Christel
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856515/
https://ncbi.nlm.nih.gov/pubmed/29463701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1713370115
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