Epigenetic reprogramming enables the primordial germ cell-to-gonocyte transition

Gametes are highly specialised cells that can give rise to the next generation through their ability to generate a totipotent zygote. In mouse, germ cells are first specified in the developing embryo as primordial germ cells (PGCs) starting around embryonic day (E) 6.251 (Fig. 1a). Following subsequ...

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Veröffentlicht in:Nature
Hauptverfasser: Hill, Peter W. S., Leitch, Harry G., Requena, Cristina E., Sun, Zhiyi, Amouroux, Rachel, Roman-Trufero, Monica, Borkowska, Malgorzata, Terragni, Jolyon, Vaisvila, Romualdas, Linnett, Sarah, Bagci, Hakan, Dharmalingham, Gopuraja, Haberle, Vanja, Lenhard, Boris, Zheng, Yu, Pradhan, Sriharsa, Hajkova, Petra
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856367/
https://ncbi.nlm.nih.gov/pubmed/29513657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature25964
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