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Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers
RNA or DNA aptamers with 2′-OMe-modifications have been pursued to increase resistance to nucleases, but have been difficult to identify because the OMe groups ablate polymerase recognition. We recently reported evolution of the thermostable DNA polymerases SFM4-6 and SFM4-9, which enable the effici...
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| Publicado en: | Chem Sci |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Royal Society of Chemistry
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5855981/ https://ncbi.nlm.nih.gov/pubmed/29568464 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc03747c |
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