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Phosphate-Catalyzed Succinimide Formation from Asp Residues: A Computational Study of the Mechanism

Aspartic acid (Asp) residues in proteins and peptides are prone to the non-enzymatic reactions that give biologically uncommon l-β-Asp, d-Asp, and d-β-Asp residues via the cyclic succinimide intermediate (aminosuccinyl residue, Suc). These abnormal Asp residues are known to have relevance to aging a...

詳細記述

保存先:
書誌詳細
出版年:Int J Mol Sci
主要な著者: Kirikoshi, Ryota, Manabe, Noriyoshi, Takahashi, Ohgi
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5855859/
https://ncbi.nlm.nih.gov/pubmed/29495268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19020637
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