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Analysis of mutations in pncA reveals non-overlapping patterns among various lineages of Mycobacterium tuberculosis

Pyrazinamide (PZA) is an important first-line anti-tuberculosis drug, resistance to which occurs primarily due to mutations in pncA (Rv2043c) that encodes the pyrazinamidase enzyme responsible for conversion of pro-drug PZA into its active form. Previous studies have reported numerous resistance-con...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Sci Rep
Main Authors: Baddam, Ramani, Kumar, Narender, Wieler, Lothar H., Lankapalli, Aditya Kumar, Ahmed, Niyaz, Peacock, Sharon J., Semmler, Torsten
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group UK 2018
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5854631/
https://ncbi.nlm.nih.gov/pubmed/29545614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22883-9
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