Rare variants in drug target genes contributing to complex diseases, phenome-wide

The DrugBank database consists of ~800 genes that are well characterized drug targets. This list of genes is a useful resource for association testing. For example, loss of function (LOF) genetic variation has the potential to mimic the effect of drugs, and high impact variation in these genes can i...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Verma, Shefali Setia, Josyula, Navya, Verma, Anurag, Zhang, Xinyuan, Veturi, Yogasudha, Dewey, Frederick E., Hartzel, Dustin N., Lavage, Daniel R., Leader, Joe, Ritchie, Marylyn D., Pendergrass, Sarah A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5854600/
https://ncbi.nlm.nih.gov/pubmed/29545597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22834-4
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