Cardiac Actions of a Small Molecule Inhibitor Targeting GATA4–NKX2-5 Interaction

Transcription factors are fundamental regulators of gene transcription, and many diseases, such as heart diseases, are associated with deregulation of transcriptional networks. In the adult heart, zinc-finger transcription factor GATA4 is a critical regulator of cardiac repair and remodelling. Previ...

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Udgivet i:Sci Rep
Main Authors: Kinnunen, Sini M., Tölli, Marja, Välimäki, Mika J., Gao, Erhe, Szabo, Zoltan, Rysä, Jaana, Ferreira, Mónica P. A., Ohukainen, Pauli, Serpi, Raisa, Correia, Alexandra, Mäkilä, Ermei, Salonen, Jarno, Hirvonen, Jouni, Santos, Hélder A., Ruskoaho, Heikki
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5854571/
https://ncbi.nlm.nih.gov/pubmed/29545582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22830-8
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