Analytical validation of a next generation sequencing liquid biopsy assay for high sensitivity broad molecular profiling

Circulating tumor DNA (ctDNA) analysis is being incorporated into cancer care; notably in profiling patients to guide treatment decisions. Responses to targeted therapies have been observed in patients with actionable mutations detected in plasma DNA at variant allele fractions (VAFs) below 0.5%. Hi...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Plagnol, Vincent, Woodhouse, Samuel, Howarth, Karen, Lensing, Stefanie, Smith, Matt, Epstein, Michael, Madi, Mikidache, Smalley, Sarah, Leroy, Catherine, Hinton, Jonathan, de Kievit, Frank, Musgrave-Brown, Esther, Herd, Colin, Baker-Neblett, Katherine, Brennan, Will, Dimitrov, Peter, Campbell, Nathan, Morris, Clive, Rosenfeld, Nitzan, Clark, James, Gale, Davina, Platt, Jamie, Calaway, John, Jones, Greg, Forshew, Tim
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2018
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5854321/
https://ncbi.nlm.nih.gov/pubmed/29543828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0193802
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