The crystal structure of the Leishmania infantum Silent Information Regulator 2 related protein 1: Implications to protein function and drug design

The de novo crystal structure of the Leishmania infantum Silent Information Regulator 2 related protein 1 (LiSir2rp1) has been solved at 1.99Å in complex with an acetyl-lysine peptide substrate. The structure is broadly commensurate with Hst2/SIRT2 proteins of yeast and human origin, reproducing man...

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Veröffentlicht in:PLoS One
Hauptverfasser: Ronin, Céline, Costa, David Mendes, Tavares, Joana, Faria, Joana, Ciesielski, Fabrice, Ciapetti, Paola, Smith, Terry K., MacDougall, Jane, Cordeiro-da-Silva, Anabela, Pemberton, Iain K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5854310/
https://ncbi.nlm.nih.gov/pubmed/29543820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0193602
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