A Molecular Assay to Quantify Male and Female Plasmodium falciparum Gametocytes: Results From 2 Randomized Controlled Trials Using Primaquine for Gametocyte Clearance

BACKGROUND: Single low-dose primaquine (PQ) reduces Plasmodium falciparum infectivity before it impacts gametocyte density. Here, we examined the effect of PQ on gametocyte sex ratio as a possible explanation for this early sterilizing effect. METHODS: Quantitative reverse-transcription polymerase c...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Stone, Will, Sawa, Patrick, Lanke, Kjerstin, Rijpma, Sanna, Oriango, Robin, Nyaurah, Maureen, Osodo, Paul, Osoti, Victor, Mahamar, Almahamoudou, Diawara, Halimatou, Woestenenk, Rob, Graumans, Wouter, van de Vegte-Bolmer, Marga, Bradley, John, Chen, Ingrid, Brown, Joelle, Siciliano, Giulia, Alano, Pietro, Gosling, Roly, Dicko, Alassane, Drakeley, Chris, Bousema, Teun
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5853855/
https://ncbi.nlm.nih.gov/pubmed/28931236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jix237
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