Monoclonal Antibody Protects Against Acinetobacter baumannii Infection by Enhancing Bacterial Clearance and Evading Sepsis

BACKGROUND: Extremely drug-resistant (XDR) Acinetobacter baumannii is one of the most commonly encountered, highly resistant pathogens requiring novel therapeutic interventions. METHODS: We developed C8, a monoclonal antibody (mAb), by immunizing mice with sublethal inocula of a hypervirulent XDR cl...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Nielsen, Travis B, Pantapalangkoor, Paul, Luna, Brian M, Bruhn, Kevin W, Yan, Jun, Dekitani, Ken, Hsieh, Sarah, Yeshoua, Brandon, Pascual, Bryan, Vinogradov, Evgeny, Hujer, Kristine M, Domitrovic, T Nicholas, Bonomo, Robert A, Russo, Thomas A, Lesczcyniecka, Magda, Schneider, Thomas, Spellberg, Brad
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5853763/
https://ncbi.nlm.nih.gov/pubmed/28931235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jix315
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