Association of Dynamic Changes in the CD4 T-Cell Transcriptome With Disease Severity During Primary Respiratory Syncytial Virus Infection in Young Infants

BACKGROUND: Nearly all children are infected with respiratory syncytial virus (RSV) within the first 2 years of life, with a minority developing severe disease (1%–3% hospitalized). We hypothesized that an assessment of the adaptive immune system, using CD4(+) T-lymphocyte transcriptomics, would ide...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Mariani, Thomas J, Qiu, Xing, Chu, ChinYi, Wang, Lu, Thakar, Juilee, Holden-Wiltse, Jeanne, Corbett, Anthony, Topham, David J, Falsey, Ann R, Caserta, Mary T, Walsh, Edward E
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5853440/
https://ncbi.nlm.nih.gov/pubmed/28962005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jix400
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