Crimean-Congo Hemorrhagic Fever in Humanized Mice Reveals Glial Cells as Primary Targets of Neurological Infection

Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral hemorrhagic disease seen exclusively in humans. Central nervous system (CNS) infection and neurological involvement have also been reported in CCHF. In the current study, we inoculated NSG-SGM3 mice engrafted with human hematopoietic CD34(...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Spengler, Jessica R, Kelly Keating, M, McElroy, Anita K, Zivcec, Marko, Coleman-McCray, JoAnn D, Harmon, Jessica R, Bollweg, Brigid C, Goldsmith, Cynthia S, Bergeron, Éric, Keck, James G, Zaki, Sherif R, Nichol, Stuart T, Spiropoulou, Christina F
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5853341/
https://ncbi.nlm.nih.gov/pubmed/28482001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jix215
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