An RNA-binding compound that stabilizes the HIV-1 gRNA packaging signal structure and specifically blocks HIV-1 RNA encapsidation

BACKGROUND: NSC260594, a quinolinium derivative from the NCI diversity set II compound library, was previously identified in a target-based assay as an inhibitor of the interaction between the HIV-1 (ψ) stem-loop 3 (SL3) RNA and Gag. This compound was shown to exhibit potent antiviral activity. Here...

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Bibliographic Details
Published in:Retrovirology
Main Authors: Ingemarsdotter, Carin K., Zeng, Jingwei, Long, Ziqi, Lever, Andrew M.L., Kenyon, Julia C.
Format: Artigo
Language:Inglês
Published: BioMed Central 2018
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5853050/
https://ncbi.nlm.nih.gov/pubmed/29540207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-018-0407-4
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