CDK5RAP3 suppresses Wnt/β-catenin signaling by inhibiting AKT phosphorylation in gastric cancer

BACKGROUND: CDK5RAP3 was initially isolated as a binding protein of the CDK5 activator p35. Although CDK5RAP3 has been shown to negatively regulate the Wnt/β-catenin signaling pathway in gastric cancer by repressing GSK-3β phosphorylation, its in-depth mechanism has not been determined. METHODS: Fol...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Zheng, Chao-Hui, Wang, Jia-Bin, Lin, Man-Qiang, Zhang, Peng-Yang, Liu, Li-Chao, Lin, Jian-Xian, Lu, Jun, Chen, Qi-Yue, Cao, Long-Long, Lin, Mi, Tu, Ru-Hong, Xie, Jian-Wei, Li, Ping, Huang, Chang-Ming
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5852959/
https://ncbi.nlm.nih.gov/pubmed/29540196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0716-4
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