Wordt geladen...

Investigations towards the stereoselective organocatalyzed Michael addition of dimethyl malonate to a racemic nitroalkene: possible route to the 4-methylpregabalin core structure

Chiral derivatives of γ-aminobutyric acid are widely used as medicines and can be obtained by organocatalytic Michael additions. We show here the stereoselective synthesis of 4-methylpregabalin stereoisomers using a Michael addition of dimethyl malonate to a racemic nitroalkene. The key step of the...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Beilstein J Org Chem
Hoofdauteurs: Vargová, Denisa, Baran, Rastislav, Šebesta, Radovan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Beilstein-Institut 2018
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5852648/
https://ncbi.nlm.nih.gov/pubmed/29623117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.14.42
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!