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Investigations towards the stereoselective organocatalyzed Michael addition of dimethyl malonate to a racemic nitroalkene: possible route to the 4-methylpregabalin core structure

Chiral derivatives of γ-aminobutyric acid are widely used as medicines and can be obtained by organocatalytic Michael additions. We show here the stereoselective synthesis of 4-methylpregabalin stereoisomers using a Michael addition of dimethyl malonate to a racemic nitroalkene. The key step of the...

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Veröffentlicht in:Beilstein J Org Chem
Hauptverfasser: Vargová, Denisa, Baran, Rastislav, Šebesta, Radovan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Beilstein-Institut 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5852648/
https://ncbi.nlm.nih.gov/pubmed/29623117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.14.42
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