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Population-specific design of de-immunized protein biotherapeutics
Immunogenicity is a major problem during the development of biotherapeutics since it can lead to rapid clearance of the drug and adverse reactions. The challenge for biotherapeutic design is therefore to identify mutants of the protein sequence that minimize immunogenicity in a target population whi...
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| Veröffentlicht in: | PLoS Comput Biol |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5851651/ https://ncbi.nlm.nih.gov/pubmed/29499035 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005983 |
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