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Population-specific design of de-immunized protein biotherapeutics
Immunogenicity is a major problem during the development of biotherapeutics since it can lead to rapid clearance of the drug and adverse reactions. The challenge for biotherapeutic design is therefore to identify mutants of the protein sequence that minimize immunogenicity in a target population whi...
Gorde:
| Argitaratua izan da: | PLoS Comput Biol |
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| Egile Nagusiak: | , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Public Library of Science
2018
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5851651/ https://ncbi.nlm.nih.gov/pubmed/29499035 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005983 |
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