SPARCL1 suppresses osteosarcoma metastasis and recruits macrophages by activation of canonical WNT/β-catenin signaling through stabilization of the WNT–receptor complex

Metastasis significantly reduces the survival rate of osteosarcoma (OS) patients. Therefore, identification of novel targets remains extremely important to prevent metastasis and treat OS. In this report, we show that SPARCL1 is downregulated in OS by epigenetic methylation of promoter DNA. In vitro...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Zhao, S-J, Jiang, Y-Q, Xu, N-W, Li, Q, Zhang, Q, Wang, S-Y, Li, J, Wang, Y-H, Zhang, Y-L, Jiang, S-H, Wang, Y-J, Huang, Y-J, Zhang, X-X, Tian, G-A, Zhang, C-C, Lv, Y-Y, Dai, M, Liu, F, Zhang, R, Zhou, D, Zhang, Z-G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2018
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5851113/
https://ncbi.nlm.nih.gov/pubmed/29084211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.403
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