No evidence for association of MTHFR 677C>T and 1298A>C variants with placental DNA methylation

BACKGROUND: 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in one-carbon metabolism that ensures the availability of methyl groups for methylation reactions. Two single-nucleotide polymorphisms (SNPs) in the MTHFR gene, 677C>T and 1298A>C, result in a thermolabile enzyme with...

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Bibliographic Details
Published in:Clin Epigenetics
Main Authors: Del Gobbo, Giulia F., Price, E. Magda, Hanna, Courtney W., Robinson, Wendy P.
Format: Artigo
Language:Inglês
Published: BioMed Central 2018
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5851070/
https://ncbi.nlm.nih.gov/pubmed/29564022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-018-0468-1
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