A Rapamycin-Based GMP-Compatible Process for the Isolation and Expansion of Regulatory T Cells for Clinical Trials

The concept of regulatory T cell (Treg)-based immunotherapy has enormous potential for facilitating tolerance in autoimmunity and transplantation. Clinical translation of Treg cell therapy requires production processes that satisfy the rigors of Good Manufacturing Practice (GMP) standards. In this r...

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Udgivet i:Mol Ther Methods Clin Dev
Main Authors: Fraser, Henrieta, Safinia, Niloufar, Grageda, Nathali, Thirkell, Sarah, Lowe, Katie, Fry, Laura J., Scottá, Cristiano, Hope, Andrew, Fisher, Christopher, Hilton, Rachel, Game, David, Harden, Paul, Bushell, Andrew, Wood, Kathryn, Lechler, Robert I., Lombardi, Giovanna
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Gene & Cell Therapy 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5850906/
https://ncbi.nlm.nih.gov/pubmed/29552576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2018.01.006
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