Overlapping recognition determinants within the ssrA degradation tag allow modulation of proteolysis

The ssrA tag, an 11-aa peptide added to the C terminus of proteins stalled during translation, targets proteins for degradation by ClpXP and ClpAP. Mutational analysis of the ssrA tag reveals independent, but overlapping determinants for its interactions with ClpX, ClpA, and SspB, a specificity-enha...

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Podrobná bibliografie

Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Flynn, Julia M., Levchenko, Igor, Seidel, Meredith, Wickner, Sue H., Sauer, Robert T., Baker, Tania A.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 2001
Témata:	Biological Sciences
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC58509/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11535833/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.191375298
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