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Overlapping recognition determinants within the ssrA degradation tag allow modulation of proteolysis
The ssrA tag, an 11-aa peptide added to the C terminus of proteins stalled during translation, targets proteins for degradation by ClpXP and ClpAP. Mutational analysis of the ssrA tag reveals independent, but overlapping determinants for its interactions with ClpX, ClpA, and SspB, a specificity-enha...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC58509/ https://ncbi.nlm.nih.gov/pubmed/11535833 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.191375298 |
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