Overlapping recognition determinants within the ssrA degradation tag allow modulation of proteolysis

The ssrA tag, an 11-aa peptide added to the C terminus of proteins stalled during translation, targets proteins for degradation by ClpXP and ClpAP. Mutational analysis of the ssrA tag reveals independent, but overlapping determinants for its interactions with ClpX, ClpA, and SspB, a specificity-enha...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Flynn, Julia M., Levchenko, Igor, Seidel, Meredith, Wickner, Sue H., Sauer, Robert T., Baker, Tania A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC58509/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11535833/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.191375298
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