Cumulus cells surrounding oocytes with high developmental competence exhibit down-regulation of phosphoinositol 1,3 kinase/protein kinase B (PI3K/AKT) signalling genes involved in proliferation and survival

STUDY QUESTION: Is the phosphoinositol 1,3-kinase/protein kinase B (PI3K/AKT) pathway expression profile in cumulus cells (CCs) a potential marker of oocyte competence and predictive of pregnancy outcome? SUMMARY ANSWER: Eleven genes (AKT1, ARHGEF7, BCL2L1, CCND1, E2F1, HRAS, KCNH2, PIK3C2A, SHC1, S...

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Publicat a:Hum Reprod
Autors principals: Artini, P G, Tatone, C, Sperduti, S, D’Aurora, M, Franchi, S, Di Emidio, G, Ciriminna, R, Vento, M, Di Pietro, C, Stuppia, L, Gatta, V
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5850344/
https://ncbi.nlm.nih.gov/pubmed/29087515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/humrep/dex320
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