miR-182-5p and miR-183-5p Act as GDNF Mimics in Dopaminergic Midbrain Neurons

Parkinson’s disease (PD) is the second-most-frequent neurodegenerative disorder worldwide. One major hallmark of PD is the degeneration of dopaminergic (DA) neurons in the substantia nigra. Glial cell line-derived neurotrophic factor (GDNF) potently increases DA neuron survival in models of PD; howe...

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Publicat a:Mol Ther Nucleic Acids
Autors principals: Roser, Anna-Elisa, Caldi Gomes, Lucas, Halder, Rashi, Jain, Gaurav, Maass, Fabian, Tönges, Lars, Tatenhorst, Lars, Bähr, Mathias, Fischer, André, Lingor, Paul
Format: Artigo
Idioma:Inglês
Publicat: American Society of Gene & Cell Therapy 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5849806/
https://ncbi.nlm.nih.gov/pubmed/29858093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.01.005
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