A mouse model of miR-96, miR-182 and miR-183 misexpression implicates miRNAs in cochlear cell fate and homeostasis

Germline mutations in Mir96, one of three co-expressed polycistronic miRNA genes (Mir96, Mir182, Mir183), cause hereditary hearing loss in humans and mice. Transgenic FVB/NCrl- Tg(GFAP-Mir183,Mir96,Mir182)MDW1 mice (Tg(1MDW)), which overexpress this neurosensory-specific miRNA cluster in the inner e...

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Publicado en:Sci Rep
Main Authors: Weston, Michael D., Tarang, Shikha, Pierce, Marsha L., Pyakurel, Umesh, Rocha-Sanchez, Sonia M., McGee, JoAnn, Walsh, Edward J., Soukup, Garrett A.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5824881/
https://ncbi.nlm.nih.gov/pubmed/29476110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21811-1
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