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Structural insights into positive and negative allosteric regulation of a G protein-coupled receptor through protein-lipid interactions
Lipids are becoming known as essential allosteric modulators of G protein-coupled receptor (GPCRs). However, how they exert their effects on GPCR conformation at the atomic level is still unclear. In light of recent experimental data, we have performed several long-timescale molecular dynamics (MD)...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5849739/ https://ncbi.nlm.nih.gov/pubmed/29535353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22735-6 |
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