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Direct coupling of detergent purified human mGlu(5) receptor to the heterotrimeric G proteins Gq and Gs
The metabotropic glutamate (mGlu) receptors are class C G protein-coupled receptors (GPCRs) that modulate synaptic activity and plasticity throughout the mammalian brain. Signal transduction is initiated by glutamate binding to the venus flytrap domains (VFT), which initiates a conformational change...
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| Опубликовано в: : | Sci Rep |
|---|---|
| Главные авторы: | , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5849714/ https://ncbi.nlm.nih.gov/pubmed/29535347 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22729-4 |
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