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A Genetically Encoded Fluorescent Probe for Detecting Sirtuins in Living Cells
Sirtuins are NAD(+) dependent protein deacetylases, which are involved in many biological processes. We now report a novel genetically encoded fluorescent probe (EGFP-K85AcK) that responds to sirtuins in living cells. The probe design exploits a lysyl residue in EGFP that is essential for chromophor...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5849259/ https://ncbi.nlm.nih.gov/pubmed/28857557 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b05725 |
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