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Intramolecular substitution uncages fluorogenic probes for detection of metallo-carbapenemase-expressing bacteria

This work reports a novel caging strategy for designing fluorogenic probes to detect the activity of β-lactamases. The caging strategy uses a thiophenyl linker connected to a fluorophore caged by a good leaving group—dinitrophenyl. The uncaging proceeds in two steps through the sulfa-releasing and s...

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Détails bibliographiques
Publié dans:Chem Sci
Auteurs principaux: Song, Aiguo, Cheng, Yunfeng, Xie, Jinghang, Banaei, Niaz, Rao, Jianghong
Format: Artigo
Langue:Inglês
Publié: Royal Society of Chemistry 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5849144/
https://ncbi.nlm.nih.gov/pubmed/29568429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc02416a
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