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Engineered Sialylation of Pathogenic Antibodies In Vivo Attenuates Autoimmune Disease
Self-reactive IgGs contribute to the pathology of autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis. Paradoxically, IgGs are used to treat inflammatory diseases, in the form of high-dose intravenous immunoglobulin (IVIG). Distinct glycoforms on the IgG constant fra...
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| Publicado en: | Cell |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5849077/ https://ncbi.nlm.nih.gov/pubmed/29275858 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.11.041 |
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