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Loss of Full-Length GATA1 Expression in Megakaryocytes Is a Sensitive and Specific Immunohistochemical Marker for the Diagnosis of Myeloid Proliferative Disorder Related to Down Syndrome

OBJECTIVES: Myeloid proliferative disorders associated with Down syndrome (MPD-DS), including transient abnormal myelopoiesis and myeloid leukemia associated with Down syndrome (DS), harbor mutations of GATA1, a transcription factor essential for erythroid and megakaryocytic development. These mutat...

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Detalhes bibliográficos
Publicado no:Am J Clin Pathol
Main Authors: Lee, Winston Y, Weinberg, Olga K, Evans, Andrew G, Pinkus, Geraldine S
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5848381/
https://ncbi.nlm.nih.gov/pubmed/29481579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ajcp/aqy001
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