A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy

Mycobacterium leprae causes leprosy and is unique among mycobacterial diseases in producing peripheral neuropathy. This debilitating morbidity is attributed to axon demyelination resulting from direct interaction of the M. leprae-specific phenolic glycolipid 1 (PGL-1) with myelinating glia and their...

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Bibliographic Details
Published in:Cell
Main Authors: Madigan, Cressida A., Cambier, C.J., Kelly-Scumpia, Kindra M., Scumpia, Philip O., Cheng, Tan-Yun, Zailaa, Joseph, Bloom, Barry R., Moody, D. Branch, Smale, Stephen T., Sagasti, Alvaro, Modlin, Robert L., Ramakrishnan, Lalita
Format: Artigo
Language:Inglês
Published: Cell Press 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5848073/
https://ncbi.nlm.nih.gov/pubmed/28841420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.07.030
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