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Metaplastic Cells in the Stomach Arise, Independently of Stem Cells, via Dedifferentiation or Transdifferentiation of Chief Cells

Spasmolytic polypeptide-expressing metaplasia (SPEM) develops in patients with chronic atrophic gastritis due to infection with Helicobacter pylori; it might be a precursor to intestinal metaplasia and gastric adenocarcinoma. Lineage tracing experiments of the gastric corpus in mice have not establi...

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Publicado en:Gastroenterology
Main Authors: Radyk, Megan D., Burclaff, Joseph, Willet, Spencer G., Mills, Jason C.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5847468/
https://ncbi.nlm.nih.gov/pubmed/29248442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2017.11.278
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